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Program subject to changes during the final organization process.
 
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Social Activities
Scientific Program
February 8, Monday
14:00 - 17:00 Registration and Poster Setup
17:00 - 17:15 Open Ceremony
17:15 - 18:45
SYMPOSIUM - “Signaling in cell death, cancer and the immune system”
Chair: Roger Chammas
17:15 - 17:45 Seamus Martin “Oncogene-mediated regulation of BH3-only proteins and cell death control”

17:45 - 18:15

Scott Lowe “Dissecting tumor suppressor gene networks in vivo”

18:15 - 18:45
Luke O’Neil “The IL-1 receptor/Toll-like receptor superfamily: 10 years of progress”
18:45 - 19:15  REFRESHMENTS
19:15 - 20:15  Keynote lecture
Ruslan Medzhitov “Social behavior of cells: cooperation, sacrifice and competition”
Chair: Karina Bortoluci
20:15-22:00  DINNER
February 9, Tuesday
9:30 - 12:30 
SYMPOSIUM - “Molecular control of cell death”
Chair: Cristina Bonorino
  
SYMPOSIUM - “Signaling to intracellular pathogens”
Chair: Rodrigo Correa Oliveira
9:30 - 10:00
Hao Wu “Structural and functional studies of death domain interactions in apoptosis”   Cox Terhorst “Dual roles for SLAM family cell surface receptors: microbial sensors and co-stimulatory molecules”
10:00 - 10:30 
Peter Vandenabeele “Molecular mechanisms of necrotic cell death”   Ricardo Gazzinelli “UNC93B1 and host resistance to intracellular protozoa”
10:30 - 10:45
Short talk: Andrew Oberst “Exploring the roles of interdomain cleavage and dimerization in caspase-8 activation”   Short talk: Ana Carolina Oliveira “Impaired innate immunity but preserved CD8+ T cell responses against Trypanosoma cruzi in TLR2-, TLR4-, TLR9- or MyD88-deficient mice”
10:45 - 11:15  COFFEE BREAK
11:15 - 11:45
Sharad Kumar “Apoptotic and non-apoptotic cell deaths in Drosophila development”   Dario Zamboni “Nod-like receptor signaling for the host resistance against intracellular pathogens”
11:45 - 12:15
Elvira Saraiva “NETosis: a conserved cell death mechanism with antimicrobial properties”  

Doug Golembock “P. falciparum DNA and hemozoin combine to cause fever in malaria”

12:15 - 12:30
Short talk: Welbert Pereira “Recovery of WASP expression increases the susceptibility to apoptosis of bcr-abl positive cells”   Short talk: Carina Lima “Activation of iNOS trough NAIP5/NLRC4/CASPASE-1 axis”
12:30 - 16:30  LUNCH, SOCIAL LIFE
16:30 - 18:00
SYMPOSIUM - “Calcium pathways”
Chair: Maristela Camargo
  
SYMPOSIUM - “Signaling in innate immunity”
Chair: Regina D´Império Lima
16:30 - 17:00
Patrick Hogan “Signaling via ORAI1 calcium channels, calcineurin, and NFAT”   Sérgio Costa Oliveira “The role of type I interferon signaling in intracellular bacterial infection”
17:00 - 17:30
Soraya Smaili “Calcium stores and signaling: elements of cell death or survival in neurodegenerative models?”   David Russell “Innate immunity and the development of active tuberculosis”
17:30 - 17:45
Short talk: Gustavo Pereira “NAADP is a second messenger that releases calcium from lysosomes: possible implication in autophagy”   Short talk: Renata Pereira “A novel signaling player in the Leishmania-host cell interaction: dsRNA-activated protein kinase R”
17:45 - 18:00
Short talk: Giuliana Mognol “Regulation of c-MYC expression by the calcineurin-NFAT1 pathway”   Short talk: Heloisa D’Avila “Role of mTOR in lipid body biogenesis and inflammatory response during experimental infection by Mycobacterium bovis BCG in mice”
18:00 - 18:30 COFFEE BREAK
18:30 - 20:00

SYMPOSIUM - “Cell cycle control”
Chair: Hugo Armelin
 

SYMPOSIUM - “Signaling in inflammation”
Chair: Patricia Bozza
18:30 - 19:00 
Steve Reed “Novel functions for Cdk2 and Cdc7 during cell cycle reentry”   Mauro Teixeira “Resolving inflammation by cyclic AMP: mechanisms and functional relevance”
19:00 - 19:30
Adriana Hemerly  “A double role of ORC1 in cell cycle control of genome integrity”   Peter Weller “Signaling mechanisms regulating human eosinophil secretion”
19:30 - 19:45
Short talk: Jose Aramburu “The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in T cells exposed to hypertonic stress”   Short talk: Marcus Andrade “Interleukin-33 and antigen synergistically amplify cytokine production in mast cells by co-operative interactions among signaling pathways and transcription factors”
19:45 - 20:00
Short talk: Matheus Dias “FGF2 targets an ‘achilles heel’ of Ras-driven mouse malignant cells”   Short talk: Josiane Neves “Cysteinyl leukotriene receptors expressed on membranes of human eosinophil granules mediate secretion directly from within eosinophil granules”
20:00 - 21:30 DINNER
20:30 - 23:00 POSTER EXHIBITION (Happy hour with lite bites)
February 10, Wednesday
9:30 - 12:30 

SYMPOSIUM - “Targeting signaling pathways in cancer”
Chair: Bruno Diaz

  

SYMPOSIUM - “Signaling in adaptive immunity”
Chair: Adriana Bonomo
9:30 - 10:00 
Vilma Martins “The functions of prion protein and its role as therapeutic target in tumors”   Vijay Kuchroo “Molecular mechanisms of induction of Th17 and Treg cells”
10:00 - 10:30
Nigel Waterhouse “Neutralizing Bcl-2 to restore sensitivity of cancer cells to immune clearance by natural killer cells”   Dan Littman “Role of microbiota in inflammatory T cell differentiation”
10:30 - 10:45 
Short talk: Miriam Werneck “Loss of the tumor suppressor Snf5 reveals an essential role for the T cell receptor in lymphomagenesis and tumor progression”   Short talk: Hod-Dvorai Reut “Unconventional function of the polycomb group proteins in differentiated T helper cells”
10:45 - 11:15 COFFEE BREAK
11:15 - 11:45
Gerry Melino “Title to be announced”   Mauricio Rodrigues “Adenoviral vaccine and a protozoan parasite differentially activate specific CD8+ T cells”
11:45 - 12:15
Carlos Gil “Translating signal transduction alterations in cancer cells into the design of clinical trials”   Mitch Kronenberg “A crucial role for HVEM and BTLA in regulating mucosal and memory T cell responses”
12:15 - 12:30 
Short talk: Luciana Pizzatti “SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia”   Short talk: Romulo Areal “Cytokine production and tissue pathology are modified by the presence of leukemia cells in graft-versus-host disease”
13:00 - 16:30 LUNCH, SOCIAL LIFE
16:30 - 18:00

SYMPOSIUM - “Regulation of Cell death”
Chair: Maria Bellio

  

SYMPOSIUM - “Signaling by TNF and TNF receptor family”
Chair: Luiz Fernando Reis
16:30 - 17:00
Marcela Lopes “Inhibition of Caspase-8 in T cells leads to expansion of
myeloid-derived suppressor cells in Leishmania major infection”		   Carl Ware “Conventional and unconventional signaling by TNF receptor superfamily”
17:00 - 17:30
Jean Pieters “Regulation of Mycobacterium tuberculosis and T cell survival through coronin 1 mediated signaling”   Henning Walczak “Novel mediators of signal transduction by TNF and TRAIL”
17:30 - 17:45
Short talk: Cinthya Sternberg “Activation of an apoptosis-like program during megakaryocitic and monocytic/macrophagic differentiation of hematopoietic cell lines”   Short talk: Guilherme Fortes “Heme induces a specialized cell death dependent of RIP1, TNFR1 and ROS”
17:45 - 18:00
Short talk: Marcia Wink “Characterization of ATP-induced cell death in the GL261 mouse glioma”   Short talk: Johan Van Weyenbergh “IFN/STAT1 and Fas/FasL signaling determine cell faith in adult T-cell leukemia”
18:00 - 18:30 COFFEE BREAK
18:30 - 20:00

SYMPOSIUM - “Signaling as target for therapeutic intervention”
Chair: Fernando Cunha

  

SYMPOSIUM - “Transcription factors”
Chair: Ulisses Lopes
18:30 - 19:00 
Emer Ferro “Intracellular peptides as novel regulators of cell signaling”   Anjana Rao “Signaling to gene expression in lymphocytes”
19:00 - 19:30
Miguel Soares “Towards a molecular basis for host tolerance to Plasmodium infection”   Sankar Gosh “Signaling to NF-kB in immune and inflammatory responses”
19:30 - 19:45
Short talk: Patricia Reis “Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by adjuvant antioxidant therapy”   Short talk: Alberto Nobrega “TLR4-dependent B cell maturation: independence and cooperation with BAFF through the NF-kB canonical pathway”
19:45 - 20:00
Short talk: Fabiana Meliso “Role of SIRT1 in the establishment of aberrant epigenetic marks during the melanocytes malignant transformation”   Short talk: Flavia Carneiro “IRF-2BP2 interacts with NFAT1 protein and repress its transcriptional activity”
20:00 - 21:30 DINNER
20:30 - 23:00 POSTER EXHIBITION (Happy hour with lite bites)
 
February 11, Thursday
9:00 - 11:00 Round Table – “Signaling in cell death, cancer and the immune system”
Chair: Marcelo Bozza
9:00 - 9:30  Rafael Linden “The prion protein and the immune system, and the other way around”
9:30 - 10:00  Sergio Lira “Chemokine receptor oncogenes”
10:00 - 10:30  Hilde Cheroutre “Omitting felony by switching fate”
10:30 - 11:00  Alexander Rudensky “Cell-mediated mechanisms of immune homeostasis”
11:00 - 12:00  Closing lecture: Doug Green “How cells die”
Chair: Luiz Vicente Rizzo
12:00 - 12:30 Poster awards and Closing ceremony
 
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